Alexander J. Stokes

  • Assistant Professor

Contact Info:

Assistant Professor Cell & Molecular Biology (John A, Burns School of Medicine, University of Hawaii)

Assistant Professor Biology (Chaminade University)

Data Scientist, Hawaii Data Science Institute (University of Hawaii)

Fellow of the Royal Society of Biology

Education

  • Ph.D. 2005, Molecular Physiology, University of Warwick, UK
  • M.Sc. 1996, MSc International Biotechnology, UK
  • H.B.O. 1996 (~B.Eng) Bioengineering, Avans University of Applied Sciences, NL
  • B.Sc. (Hons) 1995, Molecular Physiology, University of Warwick, UK

 

Research Interests

I am interested in ion channel biology, data science and data visualization, and business development.

 

Recent Publications

  • Myrcene and terpene regulation of TRPV1. Jansen C, Shimoda LMN, Kawakami JK, Ang L, Bacani AJ, Baker JD, Badowski C, Speck M, Stokes AJ, Small-Howard AL, Turner H. Channels (Austin). 2019 Dec;13(1):344-366. doi: 10.1080/19336950.2019.1654347. Channels (Austin). 2019 PMID:31446830

 

  • Insulin-induced lipid body accumulation is accompanied by lipid remodeling in model mast cells. Aldan JT, Jansen C, Speck M, Maaetoft-Udsen K, Cordasco EA, Faiai M, Shimoda LMN, Greineisen WE, Turner H, Stokes AJ. Adipocyte. 2019 Dec;8(1):265-279. doi: 10.1080/21623945.2019.1636624. Adipocyte. 2019 PMID:31311389

 

  • In vitro exposure to Hymenoptera venom and constituents activates discrete ionotropic pathways in mast cells. Jansen C, Shimoda LMN, Starkus J, Lange I, Rysavy N, Maaetoft-Udsen K, Tobita C, Stokes AJ, Turner H. Channels (Austin). 2019 Dec;13(1):264-286. doi: 10.1080/19336950.2019.1629225. Channels (Austin). 2019 PMID:31237176
  • Diverse TRPV1 responses to cannabinoids. Starkus J, Jansen C, Shimoda LMN, Stokes AJ, Small-Howard AL, Turner H. Channels (Austin). 2019 Dec;13(1):172-191. doi: 10.1080/19336950.2019.1619436. Channels (Austin). 2019 PMID:31096838 | PMCID:PMC6557596

 

  • Calcium-dependent, non-apoptotic, large plasma membrane bleb formation in physiologically stimulated mast cells and basophils. Jansen C, Tobita C, Umemoto EU, Starkus J, Rysavy NM, Shimoda LMN, Sung C, Stokes AJ, Turner H. J Extracell Vesicles. 2019 Feb 20;8(1):1578589. doi: 10.1080/20013078.2019.1578589. eCollection 2019. J Extracell Vesicles. 2019 PMID:30815238 | PMCID:PMC6383620

 

  • TRPV1 is a component of the atrial natriuretic signaling complex, and using orally delivered antagonists, presents a valid therapeutic target in the longitudinal reversal and treatment of cardiac hypertrophy and heart failure”. Horton JS, Shiraishi T, Alfulaij N, Small-Howard AL, Turner HC, Kurokawa T, Mori Y, Stokes AJ. Channels (Austin). 2019 Dec;13(1):1-16. doi: 10.1080/19336950.2018.1547611. Channels (Austin). 2019 PMID:30424709 | PMCID:PMC6298697

 

  • Cannabinoids, the Heart of the Matter. Alfulaij N, Meiners F, Michalek J, Small-Howard AL, Turner HC, Stokes AJ. J Am Heart Assoc. 2018 Jul 13;7(14). pii: e009099. doi: 10.1161/JAHA.118.009099. Review. No abstract available. J Am Heart Assoc.  2018 PMID:30006489 | PMCID:PMC6064852

 

Patents.

 

Method and system for simulating, predicting, interpreting, comparing, or visualizing complex data. WO2018140839A1

 

Methods and compositions for prevention and treatment of cardiac hypertrophy, US10137123B2