ABOUT EVENT

Bioinformatics Core Sponsored Seminar

Date: Thursday, October 20,  12:00 PM HST

Zoom link: https://hawaii.zoom.us/j/92124491501

Meeting ID: 921 2449 1501
Passcode: QHS646

A key challenge in medicine and biology is to develop a complete understanding of the genomic architecture of
disease. Yet the increasingly wide availability of ‘omics’ and clinical data, including whole genome sequencing,
has far outpaced our ability to interpret these sequences. Challenges include interpreting the 98% of the genome
that is noncoding to identify variants that are functional and may lead to disease, detangling genomic signals
regulating cell-lineage-specific gene expression, and mapping the resulting genetic circuits and networks in
disease-relevant cell-types to specific phenotypes and clinical outcomes. I will discuss methods that address
these challenges, and highlight their applications to cancer and mental health disorders.